The development of phospholipids based drug delivery systems have been proven prominent by the emergence of many phospholipid-related drug formulation. The variation of the length and the saturation, the bonding position of fatty acyl chains to glycerol backbone as well as the head group type become a crucial part of their application, for instance in drug delivery systems. On the other hand is the hydrophobic fatty acyl chains distinguished as the tails. On the one hand is the hydrophilic group renowned as the head group which then becomes the basis of species classification of phospholipids, such as phosphatidylcholine (PC), phosphatidyletanolamine (PE), and phosphatidylserine (PS). They are amphiphilic molecules which usually built by glycerol backbone with two different polarity groups attached to it. Phospholipids are major constituent of cellular membrane hence they have excellent biocompability. It had high encapsulation efficiency and addition of cholesterol to the liposome membrane only slightly reduced the efficiency. CocoPEs showed great potency as encapsulation material. All of CocoPEs liposomes encapsulation efficiency with cholesterol concentration up to 30% were above 80%. The temperature (Tp) was at 25.29☌ for changing from planar-shaped gel to rippling phase, 32.62☌ (Tm) for major transition from gel to liquid crystal, and 65.53☌ (Th) from liquid crystal to hexagonal phase. planar-shape gel phase, rippling phase, liquid crystal phase and hexagonal phase. At least four different phases were identified on CocoPEs i.e. The fatty acyl chains of the species were capric, linoleic, oleic, stearic and arachidic acyl chains. At least 15 species were found in coconut phosphatidylethanolamine. The purpose of this study was to isolate the ethanolamine species of coconut phospholipid and to investigate their potency as drug delivery system by using it to encapsulate vitamin C. The study consisted of two stages: the first stage was isolation and characterization of coconut phosphatidylethanolamine species and the second stage was utilization of coconut phosphatidylethanolamine liposomes to encapsulate vitamin C. A dark brown gel of coconut phosphatidylethanolamine species (CocoPEs) was isolated from dried coconut meat (9.3×10−3%, w/w).
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Both the internal operational amplifiers are of high gain and can be easily derived from single or dual power supply. The IC is consisting of two separate operational amplifiers in a single package. One of the most used package is 8 pin dip package. Of that kind, amplifiers are used in a variety of electronic circuits. LM358 Description: LM358 is an operational amplifier 8 pin IC available in different packages. The voltage adder circuit is simple to recognize and allows multiple signals to link together. The term summing amplifier is used to add two signal voltages. Here you can see the practical implementation of the LM358 Opamp adder circuit including two separate batteries, a sum of two input voltages (alternate voltage 4 Vdc and ~2.6 Vdc), and you can see in Multimeter the sum of two input voltages (6.89v). The production of the output voltage is now the sum of the inputs and is negative since the input provides the non-inverting terminal. And the voltage at point B will be the same as the voltage at point A, 0V, as seen in a closed-loop structure, which indicates that current I1 and I2 will be passing into resistor Rf (higher potential) rather than into the inverting terminal (lower potential) of the Op-amp. Brief Description: LM358 is a dual op-amp IC integrated with two op-amps powered by a common power supply. They can also be found in advanced packages SOIC, VSSOP, TSSOP. Produced in several types of package design, for bulk DIP and surface mount on a board SO. The Inverting Adder Circuit can be seen here with two inputs on the inverting input. LM358 Pinout The LM358 consists of two operational amplifiers, each with 4 pins that have a different purpose. 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